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James Sacchettini
- Rodger J. Wolfe-Welch Foundation Chair, Science; Professor, Biochemistry & Biophysics, Chemistry
- Focus Area: Drug discovery and disease-related structural biology, including Tuberculosis, Malaria, Cryptosporidiosis, Chagas disease, Cancer, and Menkes syndrome (NOT CURRENTLY TAKING GRADUATE STUDENTS)
- Office:
- ILSB 2138A
- Email:
- [email protected]
- Phone:
- 979-862-7636
Education
- Undergraduate Education
- B.S. 1980
- Graduate Education
- Ph.D. 1987
- Postdoc. 1990
Areas of Expertise
- X-ray crystallography
- Structural Biology
- Protein Biochemistry
Professional Summary
Crystallography / Drug Design
My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only beginning to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate and prevents the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research, and clinical research.
Publications
- View publications on PubMed