The Distinct Roles of Copper Transporters ATP7A and ATP7B in Mammalian Cell Physiology
Svetlana Lutseno
Associate Director for Basic Science and Clinical Relations, Institute for Basic Biomedical Sciences, Johns Hopkins University
March 27, 2024
Seminar Details
Host: Vishal Gohil
Time: 4:00 pm
Location: BCBP 108
Seminar Abstract
The copper transporters ATPases ATP7A and ATP7B are essential for mammalian physiology. Inactivation of these transporters causes severe metabolic and neurodegenerative disorders, Menkes disease and Wilson disease, respectively. ATP7A and ATP7B are biochemically and structurally similar; however, in cells they have non-overlapping functions. Following a brief description of the biochemical and structural features of these two transporters, the examples of small intestine, choroid plexus, and noradrenergic neurons will be used to illustrate the distinct cellular functions of ATP7A and ATP7B.