Svetlana Lutseno

Seminar Details

Host: Vishal Gohil

Time: 4:00 pm

Location: BCBP 108

Seminar Abstract

The copper transporters ATPases ATP7A and ATP7B are essential for mammalian physiology. Inactivation of these transporters causes severe metabolic and neurodegenerative disorders, Menkes disease and Wilson disease, respectively. ATP7A and ATP7B are biochemically and structurally similar; however, in cells they have non-overlapping functions. Following a brief description of the biochemical and structural features of these two transporters, the examples of small intestine, choroid plexus, and noradrenergic neurons will be used to illustrate the distinct cellular functions of ATP7A and ATP7B.