Dr. Hongxu Ding

Seminar Details

Host: Dr. Mingyuan Zhu

Time: 4:00pm-5:00pm

Location: BICH 108

Seminar Abstract

  

The cellular epitranscriptome, which refers to the ensemble of RNA modifications, plays critical roles in diverse biological processes ranging from physiological conditions to diseases. The emerging nanopore sequencing is uniquely positioned to profile cellular epitranscriptome, by encoding RNA modifications into characteristic electric signals. In the seminar, I will be reporting our recent progress on the development of a generic bioinformatic pipeline for nanopore sequencing-based RNA modification detection, followed by biological applications in 1) elucidating transposable element-mediated epitranscriptomic regulations in human pluripotent stem cells; 2) the quality control of therapeutic RNAs.